Correlation Between the Suitability of Empirical and Definitive Therapies According to Culture Results with the Clinical Outcomes of Patients with Bacteremia Due to Carbapenem- Resistant Acinetobacter baumannii (CRAB) at Dr. Soetomo Tertiary Referral Hosp

Carbapenem administration is an important therapy for nosocomial infections due to MDRO, especially Acinetobacter baumannii. The global increase in carbapenem-resistant A. baumannii (CRAB) that causes this pathogen has significantly threatened public health the lack of adequate treatment options very few currently available antimicrobial agents actively fight CRAB. Antimicrobial resistance a major negative impact inappropriate prescribing. Ineffective empiric (initial antibiotic regimen not sensitive identified pathogens based on vitro sensitivity test results) associated with higher rate deaths compared effective treatment. In study, we analyzed correlation between suitability and definitive antibiotics clinical outcomes patients bacteremia CRAB treated inpatient ward Dr. Soetomo Tertiary Referral Hospital, Surabaya. There were 227 isolates CRAB, consisting 156 baumanni 71 carbapenem-sensitive 88 met inclusion exclusion criteria, all them resistant ceftriaxone, cefepime, ciprofloxacin. A total 29.5% cotrimoxazole, 3.4% tigecycline, 2.3% amikacin, levofloxacin, cefoperazone sulbactam. Adequate empirical (sensitive culture test) amounted 12.5% 27.3%, respectively. no significant therapies patients' (death length stay).